Xenotransplantation offers a potential solution to the shortage of available human organs for transplantation. Significant progress over the past 3-5 years has pushed xenotransplantation to the brink of clinical translation. In this presentation, we will review recent progress in xenotransplantation, highlighting the UAB experience with the Parsons model of decedent human xenotransplantation, and discuss the potential paths forward for xenotransplantation to become a clinical reality.