Purpose: Extracorporeal membrane oxygenation (ECMO) has emerged as a salvage therapy in refractory respiratory failure. Within the literature, there is evidence to support the use of ECMO in severe thoracic trauma; however, there is minimal information on its applicability in mild-moderate thoracic trauma. This case highlights the role of ECMO in mild-moderate thoracic trauma and the multidisciplinary effort among trauma surgeons, intensive care physicians, and ECMO specialists in successfully managing a severe traumatic respiratory failure post-MVA. Methodology: This case describes a 55 year old male who presented to the emergency department of an urban, tertiary teaching hospital following a motorbike accident at approximately 50km/hr, landing on his left side. CT trauma series demonstrated a moderate left pneumothorax, small left haemothorax and left fourth-eighth rib fractures. Results: Despite maximal medical therapy, this patient's respiratory function deteriorated, commencing non-invasive ventilation (NIV) and requiring insertion of an intercostal catheter for recurrent pneumothorax. Despite NIV commencement, oxygenation worsened and the patient received emergent intubation on day 1 post injury. Given his high positive end-expiratory pressure requirement, the patient proceeded to veno-venous ECMO on day 5 post-injury, where he was optimised on the general surgical ward prior to discharge with excellent functional recovery. Conclusion: Following failure of maximal medical therapy and careful patient selection within discussions from a multidisciplinary team of trauma surgeons, intensive care physicians, and ECMO specialists, ECMO became a salvage therapy for this patient leading to successful recovery.