Purpose: The review cases where Biodegradable Temporising Matrix (BTM) has been used to reconstruct a squamous cell carcinoma (SCC) resection defect, with adjuvant radiotherapy conducted before BTM deamination. Methods: Cases were identified from a single centre with electronic medical records and clinical images used to assess patient outcomes. Results: Four cases were identified, with a mean age of 60.5 years, ranging from 49 to 90. Three cases involved resection of a T3 SCC, with one case being a T4. All cases were deemed unfavourable for a more complex soft tissue reconstruction due to either medical comorbidities or unfavourable regional vascular anatomy. All patients proceeded to radiation with the BTM laminate in situ. Delamination occurred at 1 month following radiation in two patients, and two months following in the remaining patients.. Two patients required splint thickness skin grafting following BTM deamination, with the other cases exhibiting epithelization of the BTM. Three cases had a satisfactory wound outcome, with all cases being healed by 1 month following delimitation. Only 1 case had wound breakdown, resulting in exposed cranium, and requiring a further reconstruction. Conclusion: This small case series shows that BTM may be a viable temporising measure when patients require adjuvant radiotherapy. To the best of our knowledge this is the first case series where the outcomes of BTM following radiation have been examined.