Purpose: The wound healing properties of honey have been employed and described by many ancient civilisations including ancient Egyptian, Greek, Chinese and Indian healers. Its range of purported applications include wound dressings, pain relief, gastrointestinal ailments and immunity. This review summarises the applications and evaluates the efficacy of medical grade honey in the management of wounds commonly encountered in plastic surgery. Its aim is to compare the applications and efficacy of honey to other widely used wound care products, and to educate surgeons and other clinicians involved in wound care. Methodology A literature review was conducted to assess the clinical effectiveness of medical grade honey in the management of various wounds, including burns, traumatic wounds, infected wounds and chronic wounds. Results Medical grade honey has demonstrated significant efficacy in reducing wound healing time and reducing microbial colonisation compared with alternative wound care options including silver dressings and silver sulfadiazine. Its natural composition minimizes the risk of antimicrobial resistance, making it a valuable adjunct in managing infected and non-healing wounds. Conclusion Honey is an ancient remedy whose properties, precise mechanisms and best applications are still being further understood as technology advances. There is high quality evidence that it is effective in managing a wide range of wounds encountered in plastic surgery.