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RACS ASC 2025
“Sweating bullets” – a series of malignant sweat gland carcinomas
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Institution: Royal Melbourne Hospital - VIC, Australia

Malignant sweat gland tumors are rare and invasive disease phenomena that often mimic common cutaneous malignancies. We report 2 cases of malignant sweat gland lesions: 1.78 year old woman with >10 year history of slow growing right prepatellar fungating malignancy – debrided as an suspected abscess 9 years prior at another centre, more recently biopsied as MD SCC. Lobulated 7x4cm soft tissue lesion with nil plane between bone on CT, nil locoregional or distant metastasis on PET. Patient and family opted for surgical excision over radiotherapy and a WLE 1.5cm down to patellar tendon and tuberosity, Medial gastrocnemius flap + SSG reconstruction. Eccrine carcinoma favouring microcystic adnexal carcinoma on histology. Declined radiotherapy due to functional status 2.28 year old male, 20 year history slow growing right elbow cystic lesion, initially thought to be arteriovenous malformation – underwent WLE and direct closure. Histology: adnexal tumor with ductal differentiation – well differentiated porocarcinoma, deep margin 2mm, peripheral 3. Wider excision 1cm – nil residual. On review of literature, there is little consensus on management around excision margins, role of sentinel lymph node biopsy and adjuvant therapies. Kucinskaite et al report a mean margin of 10.1mm in 20 patients, recommending wider margin with larger lesions. Tsunoda reported a series of 12 sentinel lymph node biopsies for porocarcinoma, finding a positive nodal metastasis rate of 37.5%. One must be aware of rare mimics such as sweat gland tumors managing a high volume of skin cancer
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Dr Minhao Hu - , Dr Neiraja Gnaneswaran -