Objective This study aims to evaluate the incidence of early post-operative complications of open radical cystectomy and determine risk factors for development of complications. Methods This retrospective study included consecutive patients undergoing radical cystectomy between 2017 and 2023 at a tertiary referral centre. Post-operative complications and re-admissions within 30 days were recorded and graded according to the Clavien–Dindo classification (CDC). Pre-operative patient, biochemical and disease factors were analysed to assess for association with development of post-operative complication. Results A total of 60 patients underwent radical cystectomy, experiencing a cumulative 67 post-operative complications. 63% (n=38) patients experienced at least one complication. The most common complication was ileus (42%), followed by urinary tract infection (22%). CDC ≥ 3 complications were experienced by 12% of patients. One post-operative death occurred. 17% of patients required re-admission within 28 days. None of the risk factors analysed were associated with development of complication in this cohort. Conclusion Morbidity following radical cystectomy is high. More than half of all patients experienced at least one complication in the 30 days following operation. Although a majority of complications were minor, high-grade complications were experienced by 12% of patients. Further research is required to identify risk factors for complication development following radical cystectomy in the Australian setting.