Purpose We present the case of a 46-year-old woman who developed a partial Horner’s syndrome following hemithyroidectomy and central neck dissection. Horner’s syndrome is a rare complication of thyroid surgery, with an incidence previously reported at 0.2%. However, most cases in the literature describe a Horner’s syndrome following thyroid surgery with associated lateral neck dissection. We aimed to review the literature of cases in which Horner’s syndrome developed as a complication of thyroid surgery without lateral neck dissection. Methodology Narrative review of the literature from the last 50 years was conducted via Pubmed. Cases of adult patients developing partial or complete Horner’s syndrome after open thyroid surgery (hemithyroidectomy or thyroidectomy, +/- central neck dissection) were included. Results In our case, the patient underwent right hemithyroidectomy and central neck dissection for a TIRADS-5 nodule. Six weeks postoperatively, the patient developed right sided facial anhidrosis and absence of right-sided facial erythema on exertion, with no eye signs. Neurologist review confirmed partial Horner’s syndrome, which eventually resolved. On review of the literature, we identified fifteen cases of Horner’s syndrome following thyroid surgery without lateral neck dissection. Interestingly, only four of these cases featured anhidrosis, the remaining eleven featuring ocular signs only; and no cases reported asymmetrical facial erythema. Four possible mechanisms of post-thyroidectomy Horner’s syndrome have been proposed. Conclusion We present a rare case of Horner’s syndrome post thyroidectomy. To our knowledge, this is the only reported case of a post-thyroidectomy partial Horner’s syndrome without ocular involvement.