Purpose: Data on optimal extent of resection for various stages of gallbladder cancer are lacking. This study aims to evaluate disease-free (DFS) and overall survival (OS) after simple (SC) versus radical cholecystectomy (RC) for gallbladder cancer in the Australian context, and assesses factors associated with post-operative morbidity. Methodology: Multi-centre, retrospective cohort analysis including all gallbladder cancer patients who underwent resection across six Australian institutions between January 2010 and January 2020. Results: Of 63 patients included, 31 underwent SC and 32 had RC. Liver and other organ resection correlated with prolonged median DFS (41.9 vs. 13.1 months, HR 0.492 [95% CI 0.245 – 0.987], p=0.042) and OS on univariate analysis of all patients (55.8% survived five years follow-up at study conclusion vs. median 18.4 months, HR 0.66 [95% CI 0.446-0.972], p=0.036) but failed to demonstrate effect on multivariable analysis (OS HR 0.31 [95% CI 0.09-1.04], p=0.057). RC was associated with a higher 30-day complication rate (n=21 [65.6%] vs. n=15 [48.4%], p=0.310) compared to SC, although not statistically significant. Neoadjuvant therapy was not utilized and adjuvant treatment used infrequently. Conclusion: Extended gallbladder cancer resection was associated with high post-operative morbidity without definitive improvement in survival. Further trials of neoadjuvant and adjuvant treatments are warranted to optimize oncological outcomes.