Background: Wound healing is a complex biochemical pathway where micronutrients play a role in essential chemical reactions and tissue regeneration. Thus, micronutrient deficiencies are a substantial but modifiable risk factor in poor wound healing and postoperative complications. Purpose: This literature review analyses the impact deficiencies in vitamins A, C, E, D, B12, iron and folate have on surgical outcome and whether preoperative supplementation optimises healing compared to untreated deficiencies. Method: A comprehensive literature search across academic databases Google Scholar, PubMed, NIH, was performed with keywords vitamin, micronutrient, deficiency, healing, and outcome. Thirty of the most relevant studies were analysed. Conclusion: Preoperative routine blood tests and screening of micronutrient deficiencies, particularly in susceptible elderly or comorbid populations, would benefit from targeted supplementation of micronutrient deficiencies prior to plastic and reconstructive surgery, in order to optimise patient outcome.[1] Notable findings included increased rates of infection and wound complications associated with vitamin D deficiencies, and prolonged healing and transfusion requirements linked with iron deficiencies.[2] Further trials could establish appropriate evidence-based protocols for specific deficiencies and organise proper preoperative management plans to optimise patient outcome and healing. References 1.Knackstedt, R. et al(2020) Evidence-Based Perioperative Nutrition Recommendations: Optimizing Results and Minimizing Risks. Plastic and Reconstructive Surgery, 146(2):p 423-435 2.Agha-Mohammadi, S.et al(2008) Potential Impacts of Nutritional Deficiency of Postbariatric Patients on Body Contouring Surgery. Plastic and Reconstructive Surgery, 122(6):p 1901-1914