Operative wound healing involves physiological processes that aim to restore the foundation and function of injured tissue. An important aspect of this process is the outcome of the postoperative scar that can dictate patient satisfaction. Platelet-rich plasma (PRP), derived from autologous blood, is rich in growth factors that promote tissue regeneration, angiogenesis, and collagen synthesis, offering promise for accelerating wound healing and minimising scarring. PRP has garnered attention in recent years for its potential to enhance wound healing, particularly in the context of surgical wounds. This literature review examines the application of PRP in plastic and reconstructive surgery, with a particular focus on its use in complex wounds and significant reconstructions, such as those seen in cosmetic, plastic and reconstructive surgery. In these fields, effective healing is critical to achieving optimal functional and aesthetic outcomes for patients. While PRP has been used in multiple surgical disciplines, sports medicine and dermatology for many years, its specific role in aesthetic procedures and traumatic maxillofacial reconstructions remains underexplored. This review aims to evaluate current research, identify gaps in existing knowledge, and assess the potential of PRP in promoting faster healing, minimising scarring, and improving cosmetic results in elective cosmetic, plastic and reconstructive surgery, as well as its potential use in conjunction with synthetic matrices.