Purpose: Curative treatment for pancreatic ductal adenocarcinoma (PDAC) requires surgical resection. Proximal PDAC are typically treated with pancreaticoduodenectomy (PD), a low-volume, high-risk procedure with high morbidity and mortality. Successful surgery requires consideration of tumour biology, as well as individual patient characteristics. Sarcopenia is a clinical syndrome defined by generalised muscle wasting, and frailty is a clinical syndrome defined by decreased physiological reserve, common in the elderly. This study aimed to assess the utility of pre-operative radiologic sarcopenia and frailty assessment on short- and long-term outcomes following PD. Methodology: Radiologic assessment of Skeletal Muscle Index, and clinical Modified Frailty Index (5-mFI) (Mogal et al.,2017), were calculated for all patients undergoing PD between 2016 and 2024 in two high-volume pancreatic resection centres, and evaluated as prognostic tools in patients having undergone PD. Results: 200 patients (median age 75 years) were included. 52% were sarcopenic, and 35% were moderately/severely frail. The following will be measured and stratified based on pre-operative sarcopenic and frailty status. a)Overall survival b)Incidence and severity of post-operative complications using Clavien-Dindo scoring c)Hospital length of stay d)Re-admission rates e)30- and 90-day mortality Conclusion: Frailty and sarcopenia are easily assessable parameters, which can be evaluated pre-operatively to risk-stratify patients prior to PD. By retrospectively evaluating these measures on post-operative morbidity and mortality at two major Australian centres, it will aid surgeons to individualise patient management in the context of PDAC.