Purpose: Wound-related complications are significant postoperative concerns following laparotomy. This study evaluates the impact of various closure techniques on these complications. Methodology: A retrospective analysis was conducted on 164 laparotomy cases at Rockhampton Hospital from January 2021 to June 2023 to assess wound-related complications, focusing on SSI and wound dehiscence. The closure techniques assessed included mass versus layered closure, suture types for fascial closure, staple versus suture skin closure, and adjunct measures such as drain use, Praveena therapy and abdominal binders. Statistical significance was determined using chi-square tests (p<0.05). Results: Wound-related complications were observed in 21.2% of cases (n=35), with SSI occurring in 17.8% (n=23) and wound dehiscence in 8.6% (n=14). The type of suture used for fascial closure showed a significant association with SSI (p=0.011). PDS was most commonly used, accounting for 82.9% of cases, with an SSI occurrence of 65.2%. Nylon sutures, utilized in 11% of cases, were linked to 17.4% of SSI cases. Mass closure was significantly associated with wound dehiscence (p=0.004), contributing to 85.7% of cases. No significant associations were identified between other closure techniques or adjunctive measures and the occurrence of SSI or wound dehiscence. Patients who developed complications had a significantly prolonged hospital stay (19.03 ± 19.42 days) compared to those without complications (12.20 ± 20.23 days; p=0.038). Conclusion: Suture type and mass closure are significantly associated with wound-related complications following laparotomy. Further prospective studies are necessary to refine closure techniques and improve patient outcomes.