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Institution: Peter MacCallum Cancer Centre - VIC, Australia
Postoperative incontinence is a significant complication following radical prostatectomy, driving the development of new techniques to improve continence rates. This study compares Retzius-sparing (RS), hood-technique and the standard robotic-assisted laparoscopic prostatectomy (RALP), assessing functional, oncological, and perioperative outcomes.
A systematic review was performed in accordance with PRISMA guidelines. The primary outcome was the postoperative social continence rate (0-1 pads/day) at 12 months. Secondary outcomes included postoperative social continence at other time points, the positive surgical margins (PSM), biochemical recurrence (BCR) at 12 months, and other perioperative measures. A meta-analysis was conducted to assess RS versus standard RALP. An exploratory meta-analysis was performed to compare the hood-technique against standard RALP. Additionally, a network meta-analysis (NMA) was performed to compare these three techniques.
The meta-analysis included 24 studies comparing RS-RALP against standard RALP and 4 studies assessing hood-technique against standard RALP, covering 5561 patients. In comparison with the standard RALP, RS-RALP demonstrated a significantly higher rate of social continence at 12 months (Risk ratio (RR) = 1.17, 95% CI 1.10 to 1.23), the hood-technique also demonstrated similar results at 12 months (RR = 1.24, 95% CI 1.13 to 1.37).
Both RS-RALP and hood-technique RALP are associated with a higher continence rate. A direct comparison between hood-technique RALP and RS RALP is recommended to determine which one provides superior functional outcomes.
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Authors
Dr Siyu Huang - , Dr David Chen - , Dr Liang Qu - , Dr Nathan Papa - , Prof Nathan Lawrentschuk - , A/Prof Marlon Perara -