Purpose: To address underrepresentation of First Nations peoples in cancer surgical trials through developing, implementing, and evaluating a community-led intervention to improve recruitment and retention of First Nations participants. Methodology: Five streams will be pursued to address the aim: 1) Community engagement and baseline evaluations (engaging First Nations community leaders, conducting a comprehensive scoping review and analysing current trial participation rates); 2) examination of Community experience (facilitating culturally safe yarning circles with First Nations patients, families and carers and conducting stakeholder interviews to identifying systemic barriers to trial participation); 3) co-designing recruitment enhancement strategy (through Community-led workshops, ensuring cultural appropriateness guided by First Nations patients and communities); 4) implementation of co-designed strategy (integrating developed intervention into current cancer surgical trials, with continuous evaluation and health economic analysis); and 5) assessment of scalability (disseminating results through Community-approved channels, embedding practices within state and national services). Results: The results of this body of work will be toward: increasing First Nations participation in cancer surgical trials; developing and supporting a culturally appropriate recruitment model; implementing a scalable intervention framework; undertaking economic evaluation of the co-designed strategy; and enhancing health equity in clinical research. Conclusion: This Community-centered approach seeks to develop, implement and evaluate a culturally safe strategy to enhance the recruitment of First Nations participants in cancer surgical trials.