Purpose Endocrine insufficiency post pancreatic surgery can have long-term effects on symptom burden and overall health outcomes; however, the reported prevalence is variable and a lack of Australian data limits the application of literature to our treatment population.1-2 Our objective was to determine the incidence and risk factors for development of endocrine dysfunction post pancreatic resection (defined as need for new pharmacological intervention). Method A retrospective audit of 108 patients who underwent pancreatic resection excluding total pancreatectomy at Townsville Hospital from June 2014 to June 2022, with a minimum follow-up time of 24 months. Results The incidence of new or worsening diabetes post-operatively was 18.3%. Insulin use increased by 13.7%, while oral hypoglycaemic agent use was unchanged. Underlying inflammatory pancreatic pathology had an increased risk of post-operative endocrine dysfunction compared to benign or malignant pathology (p = 0.019). There was no significant association with pre-operative bilirubin level, procedure type, or approximate resection volume. Conclusion This study demonstrates the incidence of endocrine dysfunction and worsening glycaemic control post pancreatic resection, and highlights the need for early diagnosis and intervention. Further research is required to evaluate risk factors facilitating pre-op prognostication. References 1. Kusakabe J, Anderson B, Liu J, et al. Long-Term Endocrine and Exocrine Insufficiency After Pancreatectomy. J Gastrointest Surg. 2019;23(8):1604-13. 2. Kanwat S, Singh H, Sharma AK, et al. Pancreatic Dysfunction and Reduction in Quality of Life Is Common After Pancreaticoduodenectomy. Dig Dis Sci. 2023;68(7):3167-73.