Purpose: Diabetic heel ulcers and calcaneal osteomyelitis is a complex and challenging pathology for the modern surgeon and is associated with high risk of morbidity and limb loss. Management often involves debridement, dressing changes, negative pressure wound therapy, and offloading. Antibiotic-loaded bone cement is frequently utilised to deliver antibiotics to site of infection. Biodegradable temporizing matrix is a novel, bilayer, synthetic skin substitute made of biodegradable polyurethane foam covered with a sealing membrane and has been used in soft tissue reconstruction. We review the literature to assess wound management outcomes involving the use of these two techniques. Methodology: A literature review was performed in MedLine, PubMed, Embase, GoogleScholar for search terms “ulcer”, “diabetes”, “wound reconstruction”, “biodegradable temporising matrix”, “biocomposite”. Results: Antibiotic-loaded bone cement is well described and reviewed in orthopaedic surgery literature. Biodegradeable temporizing matrix has shown excellent outcomes in burns literature. There are limited articles describing the use of both techniques in management of diabetic foot ulcers in vascular surgery literature. Conclusion: A multidisciplinary approach is crucial in managing heel ulcers with underlying calcaneal osteomyelitis. The method of debridement, injection of antibiotic-impregnated cement, followed by matrix application is a valid method in managing complex wounds with comparable outcomes. In diabetics and peripheral vascular disease patients, initial revascularisation should be considered to optimise arterial supply for wound healing. Further observational studies are needed to assess long-term outcomes.