Background: Surgical debridement remains the gold standard treatment in eliminating serious wound infections with clear recommendations through established guidelines. Antibiotics have had an unclear role in their efficacy and necessity post-debridement.[1] Purpose: This review aims to clarify the role of antibiotic therapy following surgical wound debridement, focusing on identifying duration, spectrum and route that provides potential superior outcomes. Method: A comprehensive literature search was completed on Google Scholar and PubMed databases using keywords surgical debridement, antibiotic, outcome, infection, soft tissue, chronic, fracture, and wounds. The thirty most relevant papers were analysed in accordance to the objective. Conclusion: Post-debridement antibiotic use varies with wound type and across institutions. Current evidence indicates that prolonged antibiotic courses offer no added benefit to shorter courses (48-72 hours) with equivalent outcomes in treating necrotising soft-tissue infections. However, in the case of fracture-related infection with retained implants, prolonged treatment is vital.[2] Gaps in evidence remain regarding optimal routes of administration, definition of adequate source control, guidelines on intermediate-risk situations and lack of randomised controlled trials.[1] Overall, practice pattens seem based on tradition and medicolegal concern rather than evidence-based recommendations. References 1.Lyons, NB, et al(2023). Short Versus Long Antibiotic Duration for Necrotizing Soft Tissue Infection: A Systematic Review and Meta-Analysis. Surgical Infections;24(5):425-432 2.Sartelli, M. et al(2022). WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections. World J Emerg Surg 17, 3