Historically, vascular anastomosis techniques employed commonly in the fields of vascular, cardiothoracic and plastic and reconstructive surgery have relied on suture-based techniques. Traditional suture based techniques for microvascular anastomosis, although effective, require high levels of skill and resources, thus prohibiting access. Non-suture vascular anastomosis represents a significant clinical advancement, with promising results of improved efficiency, reliability, patency rates, lower cost and faster recovery time. Here a review of a variety of sutureless vascular anastomosis techniques including, bio-adhesives, photo-chemical tissue bonding, laser-based tissue welding, and extra and intra-luminal mechanical coupling devices is discussed. A summary of the material composition, potential for intimal trauma, vessel compatibility, patency rates, complications and challenges for these non-suture vascular anastomosis techniques is presented.