Background: Complex wounds in immunocompromised patients can be clinically challenging to manage and often the only option is specialised dressings, however, evidence for which dressings are suitable, indicated and safe in such patients, remains limited.[1] Purpose: This study investigates whether advanced wound dressings perform differently in high-risk patients. Method: Academic databases Google Scholar and PubMed were utilised to conduct a literature search with keywords immunocompromised, high-risk, diabetic, smoker, vascular disease, transplant patients, wound dressings. Thirsty of the most relevant papers were analysed. Conclusion: Advanced wound dressings have variable efficacy in high-risk and immunocompromised patients due to impaired systemic healing pathways, increased risk of infection and delayed healing and recovery. Evidence suggest NPWT and antimicrobial dressings with active ingredients have a superior outcome in high-risk patients, whereas occlusive and adherent dressings may be troublesome, depending on patient factors.[2] Dressings should be individualised and chosen in regard to wound type, immune status, and risk of infection, where ongoing research targeting comparative studies and dressing-host interactions would be beneficial. References 1.Greer, N. et al(2013). Advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers: a systematic review. Annals of internal medicine, 159(8), 532–542 2.Shan, H. et al(2023). Incisional Negative Pressure Wound Therapy Impacts on Wound Healing and Quality of Life Following Lower Extremity Amputation: A Prospective Randomized Control Trial. Plastic and Reconstructive Surgery Global Open, 11(10 Suppl), 99